Bee?s Venom (BV) has been used in Korea to alleviate pain symptoms, and to treat inflammatory conditions, such as rheumatoid arthritis. The underlying mechanisms of BV?s anti-inflammatory and pain-reducing action have been demonstrated to a certain point. Moreover, recent clinical and experimental studies have shown that the derivative active components of BV are applicable to a large range of immune and neurodegenerative diseases, including autoimmune diseases and Parkinson?s disease. It is known that these effects of the BV are caused by the modulation of immune peripheral cells, as well as glial cells and neurons in the central nervous system. This opinion will present scientific evidence of the therapeutic effects of BV and its components on several immune and neurological diseases. It will also describe the detailed mechanisms involved in the regulation of several immune responses, and the pathological changes to the glia and neurons.
